Strengthening Individual Memories by Reactivating Them During Sleep

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Strengthening individual memories by reactivating them during sleep.

While asleep, people heard sounds that had earlier been associated with objects at specific spatial locations. Upon waking, they recalled these locations more accurately than other locations for which no reminder cues were provided. Consolidation thus operates during sleep with high specificity and is subject to systematic influences through simple auditory stimulation.

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EMBARGOED UNTIL 2PM U.S. EASTERN TIME ON THE THURSDAY BEFORE THIS DATE: Strengthening Individual Memories by Reactivating Them During Sleep

Initially fragile memories can gain stability via consolidation, but the extent to which sleep contributes to this process is unresolved (1, 2). Sleep between encoding and retrieval, relative towakefulness, promotesmemory storage in some circumstances, perhaps from internally generated memory reactivation (3, 4). Moreover, reinstating a learning context (an odor) during slow-wave sleep enhances...

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Strengthening Procedural Memories by Reactivation in Sleep

There is robust evidence that sleep facilitates procedural memory consolidation. The exact mechanisms underlying this process are still unclear. We tested whether an active replay of prior experience can underlie sleep effects on procedural memory. Participants learned a finger-tapping task in which key presses were associated with tones during practice. Later, during a consolidation interval s...

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Reactivating Memories for Consolidation

The consolidation of memory is thought to occur via a hippocampal-neocortical dialog involving reactivation of memory patterns in the hippocampus during sharp-wave ripples. In this issue of Neuron, Nakashiba et al. demonstrate that CA3 output is required for consolidation of contextual fear memory. They also show that lack of CA3 output results in a decrease in ripple-related reactivation, prov...

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Modifying memory: selectively enhancing and updating personal memories for a museum tour by reactivating them.

Memory can be modified when reactivated, but little is known about how the properties and extent of reactivation can selectively affect subsequent memory. We developed a novel museum paradigm to directly investigate reactivation-induced plasticity for personal memories. Participants reactivated memories triggered by photos taken from a camera they wore during a museum tour and made relatedness ...

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ژورنال

عنوان ژورنال: Science

سال: 2009

ISSN: 0036-8075,1095-9203

DOI: 10.1126/science.1179013